Disorders Ca2+ homeostasis in rat cardiac mitochondria affected by adriamycin.
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概要
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To determine the mechanism of adriamycin (ADR) induced cardiotoxicity, the effects of ADR on the Ca<SUP>2+</SUP> uptake and release of cardiac mitochondria were investigated. Male Wistar rats were injected intraperitoneally with 4 mg/kg body weight of ADR for 6 consequtive days, and mitochondria were isolated from heart muscle. Ca<SUP>2+</SUP> uptake and release of cardiac mitochondria were measured spectrophotometrically using a metallochromic dye antipyrylazo III. The total calcium content was determined by atomic absorption. ADR administration resulted in reductions of the Ca<SUP>2+</SUP> uptake velocity, Na<SUP>+</SUP>-Ca<SUP>2+</SUP> exchange velocity and the calcium content in cardiac mitochondria. The data reported here is useful for understanding the pharmacological effect of adriamycin to unfavourable side-effect, cardiotoxicity.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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KAGIYAMA AKIHIRO
Department of Medical Biochemistry, Kurume University School of Medicine
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SHIN GENKO
Department of Medical Biochemistry, Kurume University School of Medicine
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- Disorders Ca2+ homeostasis in rat cardiac mitochondria affected by adriamycin.