T2 Mapping of Muscle Activity using Ultrafast Imaging
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概要
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Measuring exercise-induced muscle activity is essential in sports medicine. Previous studies proposed measuring transverse relaxation time (T2) using muscle functional magnetic resonance imaging (mfMRI) to map muscle activity. However, mfMRI uses a spin-echo (SE) sequence that requires several minutes for acquisition. We evaluated the feasibility of T2 mapping of muscle activity using ultrafast imaging, called fast-acquired mfMRI (fast-mfMRI), to reduce image acquisition time. The current method uses 2 pulse sequences, spin-echo echo-planar imaging (SE-EPI) and true fast imaging with steady precession (TrueFISP). SE-EPI images are used to calculate T2, and TrueFISP images are used to obtain morphological information. The functional image is produced by subtracting the image of muscle activity obtained using T2 at rest from that produced after exercise. Final fast-mfMRI images are produced by fusing the functional images with the morphologic images. Ten subjects repeated ankle plantar flexion 200 times. In the fused images, the areas of activated muscle in the fast-mfMRI and SE-EPI images were identical. The geometric location of the fast-mfMRI did not differ between the morphologic and functional images. Morphological and functional information from fast-mfMRI can be applied to the human trunk, which requires limited scan duration. The difference obtained by subtracting T2 at rest from T2 after exercise can be used as a functional image of muscle activity.