肝機能亢進条件下の肝臓の生体顕微鏡観察-1-
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概要
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Mice were used for the study. The liver was examined microscopically without severance from the body (transillumination method) following the injection of a hepatotonica or a choleretica into the caudal vein. The following conclusions were made as based on the observations.1. Calcium paraoxybenzoate, sodium paraoxybenzoate and sodium hippurate increased the blood stream velocity and the blood flow. Calcium paraoxybenzoate seemed more effective in this respect than the sodium salt.2. Sodium dehydrocholate increased the velocity, but the increase of the blood volume was not marked. Intercellular spaces of the liver were dilated considerably and the bile production was augmented by this compound. It appeared that the stegnation of the bile occurred temporarily in the intercellular space due to choleresis.3. No. demonstrable change was induced by the administration of sodium thiosulfate.4. ACTH was most effective in accelerating the blood stream. Some evidence was obtained that ACTH renders the damage of cells by carbon tetrachloride less severe and restores the normal blood flow quickly.5. After the injection of dye-stuffs such as azorbin S, bromsulfalein, phenolsulfonph-thalein, scarlet red and fluorescein, the color was recognized in the blood stream. The interceliular spaces were seen dilated and the pigment granules appeared therein.6. If the injection of a dye was followed by the administration of a choleretica or a hepatotonica, the pigment granules disappeared more rapidly than in those receiving only a dye. Sodium thiosulfate was without effect in accelerating the dye excretion.
- 社団法人 日本内科学会の論文