抗体産生機構に関する研究第4編 : 家兎に於けるツベルクリン・アレルギーの受身伝達に関する研究
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概要
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In order to elicit the information concerning the mechanism of tuberculin-allergy and the antibody formation centers, the possibility of passive transfer of tuberculin hypersensitivity was tested under the following conditions: 1) When living cells isolated from such organs and tissues as the lung, spleen, lymph nodes, bone-marrow, liver and milky spots were transplanted from rabbits sensitized to tuberculin to non-sensitized rabbits. 2) When the above mentioned cells were destroyed and lysed by freezing and thawing or exposing to super-sound waves and transplanted from sensitized rabbits to nonsensitized ones. 3) When the living cells were transplanted from sensitized rabbits to non-sensitized guinea pigs. Results: 1) Even in rabbits, as in Chases report on guinea pigs, passive transfer of the tuberculin type of hypersensitivity was possible by means of transplantation of the living cells isolated from the spleen and lymph nodes. Moreover 2) the living cells of lung sensitized also had the ability to transfer successfully and surely this type of hypersensitivity. But 3) When all these cells transplanted were destroyed, they lost this ability. 4) The cells of bone-marrow, liver and of milky spots, even in the living state, and the plasma in the sensitized rabbits had probably no such ability. 5) Passive transfer of the tuberculin type of hypersensitivity between heterogenic animals appeared unsuccessful, even though the living cells of the spleen and lymph nodes which were assured to have the ability of transferring successfully the hypersensitivity between homogenous animals, were transplanted.
- 社団法人 日本内科学会の論文