KIK因子に関する研究 : 第1編KIK因子の構成アミノ酸について
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概要
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KIK reaction has been named to a biological diagnostic method of stomach cancer based on the anemiogenic activity of the gastric juice taken from the patients with stomach cancer when injected to a rabbit. The KIK factor, a substance that presents the anemiogenic activity has been presumed to be one of the simple from polypeptide and it has been successfully isolated from cancerous gastric juice and ascitic fluid. This KIK factor was hydrolized with 6N-hydrochloric acid to be placed on two dimensional paper chromatograply for the analysis of its amino acid constituents in this report. Amino acids that were found to constitute the factor were such as glutamic acid, arginine, glycine, serine, lysine, valine, leucine, phnylalanine, tyrosine, proline, alanine, aspartic acid, and those which were apparently increased in the amount were arginine, lysine, leucine, phenylalanie. Tyrosine was present only in cancerous ascitic fluid.
- 社団法人 日本内科学会の論文