慢性肺気腫患者の肺動脈圧にかんする研究
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概要
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The Studies on pulmonary arterial pressure were made by the pulmonary arterial catheterization on 53 patients with chronic pulmonary emphysema, and the following results were obtained.1) The pulmonary arterial mean pressures of these patients were 9-66mmHg, the pulmonary arterial systolic pressures 9-121mmHg, the pulmonary arterial diastolic pressures 0-36mmHg.The fluctuation of the pulmonary arterial pressure by respiration was in the rarge of 0-20mmHg in systole and 0-25mmHg in diastole and was marked in the patients with high total pulmonary vascular resistance.No significant relation between the age of the patients and level of pulmonary arterial pressure was recognized.2) Many patients with high pulmonary arterial pressure had high ratioes of residual volume and dead space ventilation. However, the patients with high ratioes of residual volume and dead space ventilation had not high pulmonary arterial pressure.3) The relationships of the haematocrit, the O2 saturation and the CO2 pressure of the arterial blood with the pulmonary arterial pressure were nearly same as the reports of many other authors.The pulmonary arterial pressures increased during low O2 inhalation and decreased during high O2 inhalation.4) During the low O2 inhalation the elevated pulmonary and systemic arterial pressures were decreased by the injection of C6 and then the total pulmonary vascular resistances resulted in decrease hand in hand. From these results, it is considered that the autonomic nervous system would be concerned with the rise of pulmonary arterial pressure during low O2 inhalation.5) The degree of the elevation of the pulmonary arterial pressure compared with the decrease of the arterial blood O2 saturation were greater during exercise than during low O2 inhalation.The elevation of the pulmonary arterial pressure during exercise may be not only due to the influence of the low O2 saturation of the arterial blood, but also due to the increased pulmonary blood flow by exercise.6) The patients with pulmonary hypertension have not always systemic hypertension, and the patients with systemic hypertension have not always pulmonary hypertension.
- 社団法人 日本内科学会の論文