Mitochondrial function of the cirrhotic liver in rat comparison of respiratory function of the mitochondria obtained from liver tissue and from isolated hepatocytes.

概要

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It is rational to evaluate the liver cirrhosis from the point of mitochondrial function. However, to obtain pure mitochondrial fraction by the fractionation from liver tissue is difficult because respiratory inhibitory factors and other material which make us underestimate the mitochondrial function can be included in thus obtained mitochondria fraction. In this study, hepatocytes are purely isolated at first, then mitochondrial fraction is obtained and evaluated in function and morphology to compare with the mitochondria fractionated directly from liver tissue in ordinary way.<BR>ATP synthesis of mitochondria fractionated directly from liver tissue was low in cirrhotic liver and got worse in long term group than short term administration group of thioacetamide. However, that of mitochondria from isolated hepatocytes showed no difference between normal and cirrhotic groups. These data suggest that, as far as hepatocyte itself is concerned, the cirrhotic liver preserves the sufficient function as well as the normal liver.
社団法人日本肝臓学会の論文