Clinical and histological studies on formation of lymphoid follicles in various liver diseases.
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概要
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To investigate the significance and the role of lymphoid follicles in the liver, clinical, histopathological and histochemical studies were performed. Three thousand cases that underwent liver biopsy were examined and lymphoid follicles were observed in 495 cases. Follicle-rich 141 cases (95 males, 46 females) were extracted for detail survey. In these cases, 131 cases (93%) were HBsAg negative. Histologically, lymphoid follicles were observed mostly in the liver of the cases with chronic hepatitis (not only chronic active hepatitis but also chronic inactive hepatitis) and nonspecific reactive hepatitis. They were sometimes ovserved in the liver diseases based on cholelithiasis, diabetes mellitus and autoimmune disease. Clinically, the cases with lymphoid follicles were characterized by hypergammaglobulinemia and slight abnormality of transaminase and had better prognosis than without lymphoid follicle. The T/B lymphocytes distribution in the follicles of the liver was similar to that of the lymphonodi.
- 社団法人 日本肝臓学会の論文