Correlation between hepatic hemodynamics and abnormality of liver morphology in patients with alcoholic liver disease.

概要

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Relationship between hepatic hemodynamics estimated by reflectance spectrophotometry and abnormality of liver morphology was investigated in 41 patients with alcoholic liver disease. The index of liver blood flow and the in vivo hepatic oxygen consumption correlated negatively with the degree of fibrosis and of hepatocyte necrosis in the whole group. On the other hand, they correlated neither the degree of fatty infiltration nor inflammation. Moreover, no significant correlation was found between the index of liver blood flow and the size of hepatocyte. When alcoholic patients without liver fibrosis were separately analyzed, there was a negative correlation between the index of liver blood flow and the degree of fatty infiltration.<BR>Thus, the main factor responsible for a decrease in liver blood flow was the fatty infiltration at an early stage of alcoholic liver disease and later, when the disease was advanced, it was the deterioration of fibrosis.
社団法人日本肝臓学会の論文