薬剤性肝障害の臨床的研究 - 自験例211例からの解析 -.

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The purposes of this study is to evaluate diagnosis, causative drugs, clinical and histological features and treatment in the 211 patients with drug-induced liver disease.<BR>The result leads to the following conclusions:<BR>1) The coincidence of positivity between the challenge tests and the immunological tests was 68.2%. 2) All cases of follow up study of LMT became negative. The shortest term was 8 days, the longest was 210 days and the mean was 87.4±67.8 days. 3) Of all causative drugs in the cases, cardiovascular agents were the most commonly encountered (32.0%) with drugs acting on the central nervous system (29.2%) and antibiotics (18.8%) next. The order of frequency of individual drugs was as follows; ajmaline, halothane, cefems and triopronine. Specific clinical and histological findings were observed with all of the drugs. 4) The factors to determine the prognosis were degree of jaundice, liver histological findings and causative drugs. 5) The clinical course in nine cases was prolonged, and six were accompanied by hypogammaglobulinemia. 6) Eight patients died and three of them had halothane hepatitis. 7) Steroid therapy was not so effective for the treatment of the drug-induced liver disease.
社団法人日本肝臓学会の論文