タイトル無し

概要

論文の詳細を見る
We studied the effect of splenectomy to the rat liver injury induced by carbon tetrachloride (CCl4). After injection of CCl4 for three months, the liver function tests in the rats, which were splenectomized prior to the peritoneal injection of CCl4, were better than those of the nonsplenectomized group. In the splenectomized rats, histologically, liver fibrosis was 50%, precirrhosis 33.3%, and cirrhosis 16.7%. On the other hand, in the non-splenectomized rats, fibrosis was 3.4% precirrhosis 17.3%, and cirrhosis 79.3%. At the level of the hepatic cells, the intracytoplasmic organelles in the splenectomized rats were more reserved than those in the nonsplenectomized rats.<BR>From the above results, it was suspected that splenectomy prior to the liver injury suppressed the advance of hepatic cell damage and fibrosis of the liver.
社団法人日本肝臓学会の論文