Analysis of the Coagulation Effect of Microwave Coagulation Therapy and Radiofrequency Ablation.

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Microwave coagulation therapy (MCT) and radiofrequency ablation (RFA) have become common therapy for liver tumors. Few reports of histological examination have used experimental model. We studied changes in liver tissue after MCT or RFA using dogs or pigs. Normal liver tissue of an anesthetized dog or pig was coagulated by MCT (Azwell Co.), RFA (Boston Scientific Japan Co.), or RFA (RITA Medical System, Inc.). In the experiment using dog livers immediately after and 5 days after operation, these apparatuses differed in coagulating the liver parenchyma macroscopically. No difference among them histologically, however, i.e., immediately after operation, hemorrhage was observed and, 5 days later, granulomatous change was observed at the marginal zone of the coagulated area. In the experiment using pig livers, RFA showed hemorrhaging immediately and 6 hours after operation and granuloma 1 week after operation at the margin of the ablated area histologically. No histological difference was seen in the ablated area based on ablation time. Both MCT and RFA showed good coagulation in liver tissue.
北関東医学会の論文