劇症肝不全で発症した悪性リンパ腫の1例

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We reported a rare case of malignant lymphoma presenting as fulminant hepatic failure. A 24 years-old female was admitted to Osaka University Hospital under the diagnosis of fulminant hepatitis. She presented jaundice and mental disturbance. Though the intensive treatments including plasmapheresis, hepatic failure progressed fatally accompanied by acute renal failure and disseminated intravascular coagulation. Histological examination of the autopsied liver showed pleomorphic lymphocytic cell infiltration mainly in the Glisson's capsule and diffuse necrosis of the hepatocytes. Atypical cells also infiltrated lymphnodes in the thoracic and abdominal cavity. Histological diagnosis was diffuse pleomorphic type lymphoma (LSG classification). Compared with viral fulminant hepatitis, laboratory data were characterized by leukopenia with atypical lymphocytes, prominent elevation of LDH, uric acid, and CRP.
社団法人日本肝臓学会の論文