原発性胆汁性肝硬変における抗糸粒体抗体亜型に関する研究
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概要
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Subtypes of antimitochondrial antibody (AMA) were investigated in patients with primary biliary cirrhosis (PBC) by an enzyme-linked immunosorbent assay (ELISA). Sixty-eight (89.5%) of 76 PBC patients were positive for anti-M2 by ELISA. Only three cases (3.9%) were positive for both anti-M2 and anti-M4 by ELISA. Two of these three patients died within one year after the manifestation of symptoms, revealing a rapid course of illness, although steroid therapy improved transientry their jaundice and clinical symptoms. Twelve (27.9%) of 43 patients who were positive for anti-M2 were also positive for anti-M8. The survival time was significantly shorter among the anti-M8 positive PBC patients by the generalized Wilcoxon test (p<0.01). Determination of subtypes of AMA in PBC is considered to be useful for diagnosis of CAH-PBC mixed type, and judging the prognosis of this disease.