高濃度エタノールの肝毒性-アルコール性肝障害の発生機序に関する検討

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The effect of a high concentration of ethanol on hepatic functions was examined in perfused rat livers. Ethanol was infused into livers in a stepwise manner from 5mM to 500mM.<BR>1. The addition of 5mM and 50mM solution of ethanol produced a mild increase in hepatic oxygen consumption with a minimal change of bile flow, hepatic contents of adenine nucleotides and hepatic energy charge.<BR>2. When ethanol from 100mM to 200mM and 500mM was infused, hepatic oxygen uptake as well as bile flow decreased dose-dependently, associated with the change of mitochondrial respiratory cytochromes to reduced form. Hepatic contents of ATP and energy charge also diminished and the diminishment was significantly correlated with the bile flow.<BR>These findings suggested that a high concentration of ethanol over 100mM or its metabolites has an inhibitory effect on mitochondrial oxidative phosphorylation, resulting in hepatic functional damage.
社団法人日本肝臓学会の論文