A case report of the liver hyperplasia developed by taking estrogen drugs.

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A case of the tumor-like lesion of the liver which developed diethylstilbestrol phosphate (DES) was reported. The patient was a 64-year old man. At this 54-years, age, prostate and testes were resected because of the prostate carcinoma and then, he was given DES in a dose of 300mg daily for ten years as an endocrine therapy. Ultrasonogram showed a hypoechoic lesion in the S<SUB>8</SUB> of the liver and celiac arteriogram revealed a hypervascular lesion in the same place. Partial subsegmentectomy of S<SUB>8</SUB> was performed because HCC was strongly suspected. Resected specimen showed a yellowish nodule but histologically, it revealed a hyperplasia of the hepatocyte without malignant change.
社団法人日本肝臓学会の論文