薬剤アレルギー性肝障害におけるリンパ球刺激試験 (LST) の基礎的検討

概要

論文の詳細を見る
The frequency of positive results reported for the lymphocyte stimulation test (LST) has varied considerably upon diagnosis of drug-induced allergic hepatic injury (DAHI). In order to clarify this relationship we defined the normal range for the stimulation index (SI) using the percentile method. Furthermore, evaluation of the optimal doses for the lymphocyte cultures in patients with DAHI induced by halothane, tiopronin, or methyldopa revealed that the optimal dose range for methyldopa was narrower than for others. The lymphocyte blastogenetic reactions under PHA or Con A in patients with hepatic injury tended to be less activated than those in the controls. These results formed a striking contrast to the LST reslults in patients with DAHI. The suppressive effect on lymphocyte proliferation induced by 20% added autologous serum could be negligible in the Con A-stimulation study.
社団法人日本肝臓学会の論文