原発性肝癌の病理形態学的研究--肝細胞癌の胆道内発育について

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There were 10 cases of hepatocellular carcinoma with intra-bile duct growth during the past 7 years, constituting 6.3% of the 158 autopsy cases. The average age of these cases was 58.5 years with a male to female ratio of 4. All of them were of the infiltrative type histopathologically, and none of them was of the expansive type according to our classification based on the growth mode. There was cirrhosis and gross invasion of tumor into the portal vein in all cases. Tumor growth was also seen in the hepatic vein in 6. Of the 10 cases, obstructive jaundice was the first presenting symptom in 3, in which obstruction of the biliary tract at the hilum by tumor and blood clot was demonstrated by autopsy. Histologically, the tip of the tumor thrombus was necrotic with bleeding, and it is believed that a blood clot formed by bleeding from the tumor thrombus.
社団法人日本肝臓学会の論文