制癌剤投与により腫瘍が完全に壊死に陥ったと考えられる原発性肝細胞癌の1症例

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A case of inoperable primary hepatocellular carcinoma in which the tumor tissue was considered to have been completely necrotized by anticancer chemotherapy was presented.<BR>The patient was a 45-year-old male who was admitted to the hospital because of pain in the right upper quadrant. On admission, there was marked hepatomegaly with a positive alpha-fetoprotein. Liver scan revealed an extensive filling defect on the inferolateral side of the right lobe, and hepatic arteriography demonstrated a prominent tumor stain along the branch to the right lobe. After 2 doses of Mitomycin C(10mg) were injected into the proper hepatic artery by intubation and 16 doses of 5-Fluorouracil (250-500mg) and Mitomycin C(4mg), 2 doses per week, were administered intravenously, subjective symptoms and hepatomegaly disappeared. Alpha-fetoprotein test converted to negative and marked improvement was noted in hepatic arteriographic findings. The patient died of acute renal failure about 3 months after cessation of anticancer chemotherapy. Autopsy demonstrated a thickly encapsulated tumor of the right lobe measuring 8×5×7cm, which was found completely necrotized.<BR>It was considered that the patient would have had a long survival if he had been free of complications.
社団法人日本肝臓学会の論文