肝障害時のケトン体代謝そのGlucose responseについて

概要

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We studied the metabolic response of ketone body to glucose load in rat liver with and without acute CCl4 intoxication. The metabolic changes after oral glucose load were as follows: 1) α-glycerophosphate concentration remained unchanged in CCl4 liver, whereas it rose to 1.7-fold above the initial level in control liver. 2) Oxaloacetate concentration dropped to about 50% below the initial level in CCl4 liver mitochondria, whereas it rose to 3-fold above the initial level in control liver mitochondria. 3) β-hydroxybutyrate/acetoacetate ratio remained statistically unchanged in CCl4liver, suggesting little suppression of the rate of oxidation of fatty acids in CCl4 liver mitochondria. 4) As the result of these evidences, acetyl-CoA concentration of CCl4 liver remained almost unchanged resulting in a little lowering of ketone body concentration in CCl4 liver.
社団法人日本肝臓学会の論文