Immunobiological function of trophoblast to circulating maternal IgG antibodies; Antibodies to major transplantation antigens.

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概要

• 論文の詳細を見る

• IgG anti-A and anti-B were isolated from one patient who showed extremely high anti-A and anti-B antibody titers by the indirect antiglobulin test. These IgG were conjugated with horseradish peroxidase (HRP). A human term placenta of blood type B from a type-O mother was incubated in a solution containing these anti-A and anti-B IgG-HRP conjugates.It is indicated that anti-A and anti-B IgG-HRP are endocytosed into the syncytiotrophoblast but these IgG-HRP lose it's character as immunoglobulin promptly after endocytosis from the results obtained, i.e., positive peroxidase reaction was widely observed inside the trophoblast but immunofluorescence carried out by use of rabbit anti-human IgG/FITC was positive only at the apical portion of the syncytiotrophoblast. On the contrary, in the control experiments used of the same placenta of the experiment and non-specific human IgG-HRP, it is verified that non-specific human IgG was transfered across the syncytiotrophoblast into the fetal side without changing its charactor as immunoglobulin.These results might support our hypothesis published in 1976, under the title of "Immunobiological Function of the Syncytiotrophoblast: A New Theory", 1 in which we explained how the fetus is prevented from circulating maternal IgG class antibodies aimed at fetal antigens, such as HLA and ABO, etc.

• The Keio Journal of Medicineの論文

著者

• MORISADA MASARU

  Department of Obstetrics and Gynecology, School of Medicine, Keio University

関連論文

• Immunobiological function of trophoblast to circulating maternal IgG antibodies; Antibodies to major transplantation antigens.

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