Tofisopam Treatment of Patients with Vertigo and Dizziness.

概要

論文の詳細を見る
The therapeutic effect of Tofisopam (150 mg/ day p.o) was evaluated in 39 patients with vertigo or dizziness. The subjective symptoms and objective findings were recorded before and four and eight, weeks after the start of treatment. After eight weeks there was marked improvement in 30.6%, moderate improvement in 19.4%, slight improvement in 41.7%, and no change in 8.3%. Clinical improvement was not quite so high after four weeks of treatment. There was no significant difference in response between peripheral vertigo and autonomic dysfunction. Clinical improvement tended to be slightly lower in patients over 50 years old than in younger patients and higher in females than in males.<BR>Many subjective symptoms, as well as vertigo and dizziness, were also reduced, such as stiff shoulder, stiff neck, headache, paresthesia and feverish sensation. The objective signs which were greatly improved were : righting reflex and gaze and positional and positioning nys-tagmus. Schellong's test, which had been positive in ten patients, became nagative in eight of them. Only one patient had any side effects : abnormal liver function tests. Tofisopam is con-siderd to be useful in the treatment of vertigo and dizziness.
一般社団法人日本めまい平衡医学会の論文