ラット心筋のオルニチン脱炭酸酵素活性に対する摂取タンパク質の影響

概要

論文の詳細を見る
Polyamines are thought to play an essential role in cell growth, proliferation and hypertrophy. Ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthesis pathway, has the shortest half-life of all mammalian enzymes studied so far, and increases rapidly in response to various growth stimuli. We investigated whether myocardial ODC activity was affected by dietary protein in rats adapted to meal-feeding. Myocardial ODC was induced significantly by feeding a casein diet but not by feeding a non-protein or a zein diet. Essentially the same results were obtained for isoproterenol-induced myocardial ODC activity, which was significantly higher in the casein-fed rats than in the starved or non-protein-fed rats. These results suggest that protein nutrition plays an important role in cardiac growth under both normal and increased sympathetic activity.