メニエール病の長期経過観察例の推移-AAOHNSの判定基準による Isosorbide の治療効果について-

概要

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In an attempt to reduce endolymphatic hydrops, Isosorbide (ISO) has been adminstered to patients with definite Meniere's disease since the beginning of the 1980s in our departments. Follow-up studies of two years or longer on 19 patients were available for analysis according to the 1985 AAO-HNS evaluation criteria.<BR>1) Vertigo: Complete control of definite attacks was achieved in seven patients (37%), substantial control in five (26%) and limited control in four (21%).<BR>2) Hearing loss: The three frequency pure-tone average at 500 Hz, 1 KHz and 2 KHz was utilized for the assessment of the hearing level. Hearing improved in five patients (26%), was unchanged in seven and deteriorated in seven.<BR>3) Disability: 14 patients (74%) were improved, while five (26%) were unchanged.<BR>These findings suggest that ISO is one of the most appropriate conservative treatment for disabling Meniere's disease.
日本めまい平衡医学会の論文