食物繊維を添加した経腸栄養剤がラット小腸の機能および絨毛の形態に及ぼす影響

概要

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We examined the effects of addition of dietary fiber to a liquid enteral diet on gastrointestinal function and morphology in rats. The following diets were given to male Wistar rats for 2 weeks: standard rat chow (5.45g/100 kcal dietary fiber, CE-2 group); a liquid enteral diet containing dietary fiber (1.0g/100kcal microcrystalline cellulose, L-X group); a liquid enteral diet containing no fiber (EN group). As parameters reflecting gastrointestinal function, gastrointestinal motility and transit time were measured. The number of beads remaining in the stomach and the mobility of beads in the small intestine were significantly lower in the EN group (p<0.01) than in the other two groups. The gastrointestinal transit time was significantly prolonged in the EN group (p<0.01) and the L-X group (p<0.05) compared with the CE-2 group. The duodenal villous height was significantly reduced in the EN group (p<0.01) compared with the other two groups, and the CE-2 group showed the highest distal ileal villous height, followed by the L-X group. These results suggest that administration of a liquid enteral diet containing fiber (microcrystalline cellulose) maintains the normal function and morphology of the gastrointestinal tract.