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When ADP was injected into an unilateral vertebral artery in the rabbit, per-rotational nystagmus decreased: slow phase eye velocity (SPEV) of the nystamus beating toward the injected side was predominantly suppressed, and directional preponderance (DP) appeared. The effects of several different drugs e. i phentoxipylline, bencyclane, ATP and ubidecarenone on the ADP-induced VOR dytfuncion were then examined. When bencyclane and phentoxipylline which are known to prevent platelet aggregation were intravenously injected prior to ADP administration, The decrease of SPEV and DP of per-rotational nystagmus following ADP injection became very small. However, when ATP and ubidecarenone which is known to stimulate cerebral metabolism was intravenously injected prior to ADP administration, these two drugs produced no significant effects upon the ADP-induced nystag-mus asymmetry. Microscopic examination revealed total or partial obstruction of a microcirculation in the cerebellum and the dorsal part of the brainstem, by the method of intrvascular injection of a contrast medium. Although administration of phentoxipylline and bencyclane moderately inhibited the ADP-induced obstruction of ricrocirculation, ATP and ubicecarenone offered no protection against the ADP-induced cerebrovascular occulsion
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