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Optokinetic nystagmus (OKN) and smooth pursuit eye movement were studied in fifteen patients with a brain tumor.<BR>In the patients with a cerebellar tumor, OKN was normal at lower stimulus velocities and substantially diminished at higher stimulus velocities, while in the patients with a brainstem tumor, it was almost completely abolished at all the stimulus velocities. In these patients, saccadic eye movement occurred instead of smooth pursuit eye movement during the eye tracking test.<BR>In one patient with a VIIIth nerve tumor localized within the porus acusticus internus, OKN was diminished at higher stimulus velocities and smooth pursuit eye movement was normal.<BR>It was concluded that a neuronal circuit in the brainstem was responsible for eliciting OKN at lower stimulus velocities, that the cerebellum provided a neuronal circuit for eliciting OKN at higher stimulus velocities and that peripheral vestibular nerve inputs produced OKN of human beings.
一般社団法人日本めまい平衡医学会の論文