Study on systemic lupus erythematosus activity and serum lymphocyte-associated immunoglobulin which is quantified with enzyme-linked immunosorbent assay

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Lymphocyte-associated immunoglobulin (LAIg) levels in the sera from patients with systemic lupus erythematosus (SLE) were quantitatively measured by means of enzyme-linked immunosorbent assay (ELISA). The relation between LAIg and SLE activity was studied. The LAIgG levels in a group of sera from untreated patients were significantly higher than those in another from treated ones. As to LAIgM, however, there was no difference between the two groups. There was a significant correlation between the serum levels of complement (CH50) and LAIgG, but no correlation between the levels of CH50 and LAIgM. The levels of LAIgG significantly correlated with those of immune complex (IC) in non-inactivated sera. After inactivation of the sera, the correlation between the levels of LAIgG and those of IC disappeared, while a significant correlation between the levels of LAIgG and those of CH50 remained. There was no correlation between titers of cytotoxicity tests and the levels of LAIgG. LAIg detected by ELISA may contain different kinds of antilymphocyte antibodies from those detected by cytotoxicity test. The serum LAIgG may play some roles in pathogenesis of SLE, since its level correlates strongly with the serum level of complement, one of the representative indicators for the SLE activity.
日本臨床免疫学会の論文