Characteristics of anti-DNA antibodies in SLE sera, with special reference to the patients with persisting high level of anti-DNA antibodies

概要

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To further clarify the clinical significance of anti-DNA antibodies in SLE, anti-DNA antibodies measured by radioassay, electrosyneresis (ES) and complement fixation technique (CF) were assessed on patients with SLE and other diseases. By radioassay, 109 of 117 sera from clinically active SLE (per cent positive; 93%, mean value; 234u/ml), 69 of 147 sera from inactive SLE (47%, 43 u/ml) and 7 of 104 sera from other diseases (7%, 9u/ml) were positive. The binding activities of the seven sera in other diseases were less than 40u/ml. Sera reacting to native DNA by ES and/or CF showed high levels of DNA binding, and some sera reacting to heat denatured DNA also showed high values by radioassay. In this series, six patients with SLE who showed persistent high levels of DNA binding and the absence of active disease for several years were recognized. In there sera, differed from results of clinically active patients, anti-DNA antibodies by ES or CF were not detected, levels of serum complement were within normal range, and values of circulating immune complex were low except for one case. A case of them possessed anti-ENA antibodies with high titers. Immunoglobulin classes of anti-DNA antibodies were investigated. In those sera, immunoglobulin class of anti-DNA antibodies belonged mainly to IgG fraction, as well as in sera from patients with clinically and serologically active SLE.
日本臨床免疫学会の論文