Neuroprotective Activity of Fructose-1,6-Bisphosphate Following Transient Forebrain Ischemia in the Mongolian Gerbil.

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概要

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• We examined the protective activity of fructose-1, 6-bisphosphate (FBP) on mortality and delayed hippocampal cell death induced by transient cerebral ischemia in the Mongolian gerbil. Forebrain ischemia was produced by bilaterally occluding the common carotid arteries for 15 min using micro-aneurysm clips; then the blood supply to the brain was restored. The number of survivors was counted for 8 days, and the histopathological damage in the CA1 region of the hippocampus was scored according to the semiquantitative scale of Rudolphi and colleagues. When injected 15 min before the ischemic insult, FBP (100 and 333 mg/kg, i.v.) significantly reduced the rate of mortality during the 8-day observation period. Equivalent doses of fructose and fructose monophosphate did not improve survival, and neither did low doses (33 mg/kg) of FBP. FBP also produced a significant degree of protection against the CA1 pyramidal cell loss in comparison with its vehicle (distilled water). Conversely, when we administered the compound, at the same dose, 15 min after the release of the arterial occlusion, we observed neither a significant reduction of mortality nor significant protection against hippocampal CA1 pyramidal cell loss. These results suggest that FBP possesses salutary properties against the damages induced by transient cerebral ischemia, although they are evident only when the compound is administered before the resolution of the ischemic injury.

• 公益社団法人 日本薬理学会の論文

著者

• Luca Roberto

  Institute of Pharmacology, School of Medicine, University of Messina

• Trimarchi Giuseppe

  Institute of Pharmacology, School of Medicine, University of Messina

• Arcadi Francesca

  Institute of Pharmacology, School of Medicine, University of Messina

• Imperatore Claudia

  Institute of Pharmacology, School of Medicine, University of Messina

• Santoro Giuseppe

  Department of Biomorphology, University of Messina

• Trimarchi Fabio

  Department of Biomorphology, University of Messina

• Costa Giovanni

  Institute of Pharmacology, School of Medicine, University of Messina

関連論文

• Neuroprotective Activity of Fructose-1,6-Bisphosphate Following Transient Forebrain Ischemia in the Mongolian Gerbil.
• MRI 3D lateral cerebral ventricles in living humans : morphological and morphometrical age-, gender-related preliminary study

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