THE NEGATIVE INOTROPIC ACTION OF NOREPINE-PHRINE IN THE PRESENCE OF OUABAIN

スポンサーリンク

概要

• 論文の詳細を見る

• Cotten and Cooper (1) showed that cardiac glycosides blocked the positive inotropic response to norepinephrine (NE) in the dog heart during hypothermia. The principal cause of its negative inotropic response to NE has been studied by some investigators. The negative inotropic response to NE is primarily the result of a decrease in the velocity of cardiac contraction (2) and its occurrence is related to the maximum plasma level of NE. The contractile force increased until the estimated plasma concentrations of NE reached 8 to 10 mμg/ml and decreased at higher concentrations. The glycosides apparently inhibited the uptake of NE by the heart (3).<BR> More detailed analyses have been performed with isolated heart preparations. The production of the negative inotropic response to NE was observed only after ouabain was given at 27°C, but ouabain had no significant effect on the contractile response to NE at 37°C in isolated guinea-pig hearts (4). On the other hand, Godfraind and Godfraind-De Becker (5), who tested the response to NE in isolated spontaneously beating guinea-pig atria treated with ouabain, noted that the negative inotropic action of NE was more marked with high concentrations or at high temperature of 37°C. They supposed that the negative inotropic response to NE was related to the toxic phase of ouabain.<BR> The present study was designed to investigate the mechanism of the negative inotropic response to NE after ouabain.

• 社団法人 日本薬理学会の論文

著者

• 中島 光好

  Departments of Pharmacology Hamamatsu University School of Medicine

• 中島 光好

  名古屋大学医学部薬理学教室

• 前田 清

  Department of Pharmacology, Nagoya University School of Medicine

• 関谷 淳

  Department of Pharmacology, Nagoya University School of Medicine

• 中島 光好

  Department of Pharmacology, Nagoya University School of Medicine

関連論文

• Analysis of the Transport of Valproic Acid into Saliva from Serum
• Effects of Losartan, an Angiotensin II Antagonist, on the Development of Cardiac Hypertrophy Due to Volume Overload
• Comparison of Electrophysiologic and Hemodynamic Effects of SD-3212,a New Antiarrhythmic Drug, and Flecainide in a Canine Myocardial Infarction Model
• 7. Bradykinin の血管作用 (第3報) : ウサギ摘出頸静脈切片における2, 3の薬物の抗 Bradykinin 作用
• ビタミンB_2テトラニコチン酸エステルにかんする研究 : (VI)循環系にたいする薬理作用
• Synergistic Interaction between Class I Antiarrhythmic Drugs and Halothane in Depressant Effects on Ventricular Activation in a Canine Myocardial Infarction Model
• Effects of Intravenous Anesthetics, Thiopental, Fentanyl, and Morphine on Ventricular Delayed Activation in a Canine Myocardial Infarction Model
• THE NEGATIVE INOTROPIC ACTION OF NOREPINE-PHRINE IN THE PRESENCE OF OUABAIN
• Digitalis葉に含まれるサポニン様物質の心臓作用に就いて
• Bradykininの心臓作用ならびにその作用に影響をおよぼす2,3の薬物について
• Bradykininの血管作用 家兎耳介動静脈のplethysmographyによる観察
• Phase I Study of Levofloxacin, (S)-(-)-Ofloxacin

もっと見る 閉じる

スポンサーリンク