HYPERURICEMIA INDUCED BY SOME ANTIHYPERTENSIVES AND URICOSURIC DRUGS IN OXONATE-TREATED RATS
スポンサーリンク
概要
- 論文の詳細を見る
Effects of antihypertensive and uricosuric drugs were studied on the plasma and urinary levels of uric acid in oxonate-treated rats. We made use of animals with a catheterized aorta to successively collect blood samples and this procedure simplified the evaluation of progressive changes of plasma uric acid, under successive loading with potassium oxonate. The plasma uric acid level of the oxonate-treated rats was increased even with a single administration of diuretic chlorothiazides, furosemide, diazoxide and also uricosuric drugs such as tienilic acid and probenecid. On the other hand, a wellmaintained plasma uric acid level was also produced by exogenously administered uric acid in rats which had been given allopurinol and potassium oxonate. Diazoxide, tienilic acid and probenecid increased the plasma uric acid, while diuretic chlorothiazides did not. Furosemide tended to decrease the plasma uric acid level at the early stage of administration to rats treated with allopurinol, oxonate and uric acid, but increased these levels several hours later when the effect was studied by uric acid loading test with rats treated with allopurinol and oxonate. These effects also appeared as changes in the urine-excreted uric acid. Thus, the oxonate-treated rats demonstrated an acutely induced hyperuricemia not only with certain antihypertensives, but also with uricosuric drugs. The utility of these procedures for evaluating the hyperuricemic and uricosuric effects of drugs is discussed.
- 社団法人 日本薬理学会の論文
著者
-
Yonetani Y
Shionogi & Co. Ltd. Osaka Jpn
-
Yonetani Yukio
Shionogi Discovery Research Laborotories Ii Shionogi & Co. Ltd.
-
ISHII Mitsuo
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
IWAKI Kazumi
Shionogi Research Laboratories, Shionogi & Co., Ltd.
-
ISHII Mitsuo
Shionogi Research Laboratories, Shionogi & Co., Ltd.
関連論文
- Dual Effects of Lsinopril on Purmycin Aminonucleoside Nephrosis in Unilaterally Nephrectomized Rats
- STIMULATION BY CATECHOLAMINE OF PURINE CATABOLISM IN RATS AND CHICKENS
- HYPERURICEMIC EFFECTS OF CHOLINERGIC AGENTS IN RATS
- EFFECTS OF URICOSURIC DRUGS AND DIURETICS ON URIC ACID EXCRETION IN OXONATE-TREATED RATS
- CATECHOLAMINE-INDUCED HYPERURICEMIA IN EVISCERATED RATS WITH FUNCTIONAL HEPATECTOMY
- Studies on Uricosuric Diuretics. II. : 6,7-Dichloro-4-nitro-, 6,7-Dichloro-4-sulfamoyl- and 6,7-Dichloro-4-acyl-2,3-dihydrobenzofuran-2-carboxylic Acids(Medeicinal Chemistry,Chemical)
- Studies on Uricosuric Diuretics. I. : 6,7-Dichloro-5-sulfamoyl-2,3-dihydrobenzofuran-2-carboxylic Acids(Medeicinal Chemistry,Chemical)
- HYPERURICEMIA INDUCED BY SOME ANTIHYPERTENSIVES AND URICOSURIC DRUGS IN OXONATE-TREATED RATS
- A new uricosuric diuretic, S-8666, in rats and chimpanzees.
- Decreased renal excretion of uric acid following diuretic administration in rats.
- A new diuretic that does not reduce renal handling of uric acid in rats, S-8666.
- Hypotensive and uric acid-retaining effects of trichlormethiazide under dietary sodium restriction in spontaneously hypertensive rats.
- The Individual Evaluating Method of the Antihypertensive Effects in Normotensive Rats (WKY) and Spontaneously Hypertensive Rats (SHR) by Biotelemetric System
- Hyperuricemia Induced by the Uricosuric Drug Probenecid in Rats.
- Circadian Rhythm of Plasma Uric Acid and Handling Stress-Induced Hyperuricemia in Conscious Cebus Monkeys.