BRAIN BENZODIAZEPINE RECEPTORS AND THEIR RAPID CHANGES AFTER SEIZURES IN THE MONGOLIAN GERBIL
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概要
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To elucidate the physiological role of benzodiazepine receptors in convulsion, these receptors were studied in the brain of the Mongolian gerbil (<I>Meriones unguiculatus</I>), an animal model used for the study of epilepsy. Benzodiazepine binding sites in the gerbil brain were demonstrated using [<SUP>3</SUP>H]diazepam. The binding was saturable and stereospecific. Benzodiazepines inhibited [<SUP>3</SUP>H]diazepam binding to the membranes and their ability to inhibit the binding closely correlated with their potency as anti-convulsants. These results showed that the characteristics of the benzodiazepine receptors in the Mongolian gerbil were similar to those obtained from rat and human brain. Seizures increase the specific binding of [<SUP>3</SUP>H]diazepam to the membranes of all regions of the gerbil brain, the most remarkable increase seen in the striatum. Time course studies showed that the increase reached a maximum 10 min after the seizure and the binding returned to the control level within 20 min. The increase in specific [<SUP>3</SUP>H]diazepam binding was due almost entirely to shifts in the affinity of [<SUP>3</SUP>H]diazepam for its receptors. Thus, the seizures may not be due to changes in the benzodiazepine receptors, and seizures produce an increase in receptor binding, which may be related to a physiological modification of excessive excitation.
- 社団法人 日本薬理学会の論文
著者
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Asano Tomiko
Department Of Biochemistry Institue For Developmental Resarch Aichi Prefectural Colony
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Mizutani Akira
Department Of Cytochemistry Chest Disease Research Institute Kyoto University
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ASANO Tomiko
Departments of Biochemistry, Institute for Developmental Research, Aichi Prefectural Colony
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