COMPARATIVE STUDY ON THE EFFECTS OF HALOXAZOLAM AND ESTAZOLAM, NEW SLEEP INDUCING DRUGS, ON THE α- AND γ-MOTOR SYSTEMS
スポンサーリンク
概要
- 論文の詳細を見る
The pharmacological actions, in vivo, of estazolam and haloxazolam were comparatively studied. Spontaneous discharges of spinal motoneurons in cats were markedly suppressed by estazolam (3 mg/kg, i.d.), but unaffected by similarly administered haloxazolam. The facilitatory effect of stimulation of the posterior hypothalamus on the γ-activity was suppressed by both haloxazolam and estazolam (3 mg/kg, p.o., for each). The stimulus threshold was raised 1.7 times by haloxazolam and 1.6 times by estazolam. The facilitation of the γ-activity induced by stimulation of the mesencephalic reticular formation was also depressed by both drugs. The stimulus threshold was raised 6 times by estazolam, but unchanged by haloxazolam. The spinal monosynaptic reflex was unaffected by haloxazolam, while its amplitude was depressed to a half by estazolam (3 mg/kg, p.o., for each). The facilitation of the monosynaptic reflex induced by conditioning stimulation was depressed by both drugs (3 mg/kg, p.o.), but estazolam showed a stronger suppressive action. The seizure-like responses of spinal motoneurons, which were induced by stimulation of the gastrocnemius nerve following strychnine administration, were unaffected by 30 mg/kg of haloxazolam, while they were suppressed by estazolam of the same dose. Thus, the results of all experiments in the present study indicate that estazolam blocks the descending activating functions of both α- and γ-motor systems, whereas the blockade by haloxazolam is limited only to the γ-system, and also that the suppressive actions of estazolam on both α- and γ-motor systems are stronger than that of haloxazolam.
- 社団法人 日本薬理学会の論文
著者
-
Sakai Yutaka
Department Of Pharmacology National Defense Medical College
-
Sakai Yutaka
Department Of Information And Computer Sciences Faculty Of Engineering Saitama University
関連論文
- Hydronephrosis caused by intra-abdominal abscess from cecal perforation by an ingested fish bone
- Transperineal extended biopsy improves the clinically significant prostate cancer detection rate : A comparative study of 6 and 12 biopsy cores
- PHARMACOLOGICAL CHARACTERIZATION OF POSTSYNAPTIC RECEPTORS FOR EXCITATORY AMINOACIDS IN PURKINJE CELL DENDRITES IN THE GUINEA PIG CEREBELLUM
- MODULATORY ACTIONS OF PROSTAGLANDINS ON CENTRAL SYNAPTIC TRANSMISSION
- Complicated urinary tract infection caused by Pseudomonas aeruginosa in a single institution (1999-2003)
- Increasing Muscle Strength and Mass of Thigh in Elderly People with the Hybrid-Training Method of Electrical Stimulation and Volitional Contraction
- INHIBITORY ACTIONS OF TAURINE AND METABOLITES ON PURKINJE CELLS IN THE CEREBELLUM
- FENTANYL AND TOOTH PULP EVOKED RESPONSES IN THE SPINAL TRIGEMINAL NUCLEUS CAUDALIS REGION
- TAURINE ACTS ON PRESYNAPTIC AUTORECEPTORS FOR GABA IN THE CEREBELLUM: EFFECTS ON Ca2+ INFLUX AND GABA RELEASE
- MANAGEMENT OF RETAINED SECUNDINES BY HYSTEROSCOPY
- COMPARATIVE STUDY ON THE EFFECTS OF HALOXAZOLAM AND ESTAZOLAM, NEW SLEEP INDUCING DRUGS, ON THE α- AND γ-MOTOR SYSTEMS
- BRAINSTEM ACETYLCHOLINE SENSITIVE NEURONS ACTIVATED BY CUTANEOUS IMPULSES IN CATS
- Computational algorithms and neuronal network models underlying decision processes
- Neuronal integration mechanisms have little effect on spike auto-correlations of cortical neurons
- Single P-element insertional mutagenesis in Drosophila melanogaster.
- Studies on the muscle relaxation effects of ethyl loflazepate (CM6912) and evaluation as an anti-anxiety drug.
- Inhibitory effect on 3H-diazepam binding and potentiating action on GABA of ethyl loflazepate, a new minor tranquilizer.