Sodium salicylate activates cathepsin B but not cathepsin H from rat spleen.
スポンサーリンク
概要
- 論文の詳細を見る
Effect of sodium salicylate (SA) and its analogues on lysosomal cysteine proteinases, cathepsins B and H, was investigated. Using a sensitive fluorometric assay, SA was shown to activate cathepsin B but not cathepsin H in the presence of cysteine. Kinetics data showed that the SA-stimulated reaction was due to a 4.5-fold decrease in K<SUB>m</SUB>. SA caused a decrease in the inactivation rate of cathepsin B by leupeptin and E-64. It was suggested that SA stimulates the activation process of the essential cysteine residue.
- 公益社団法人 日本薬理学会の論文
公益社団法人 日本薬理学会 | 論文
- Neurotoxin A2NTX Blocks Fast Inhibitory and Excitatory Transmitter Release From Presynaptic Terminals
- Loxiglumide, L - 364,718 and L - 365,260 Prevent the Inhibition of Spontaneous Acetylcholine Release from the Frontal Cerecral Cortex of Freely Moving Rat Peripherally Administered with Cholecystokinin - 8S
- A new device for the determination of microsomal cytochrome P-450 in renal tissue preparations from various species contaminated with mitochondria and hemoglobin.
- Leukocyte Recruitment to Peritoneal Cavity of Rats Following Formalin Injection : Role of Tachykinin Receptors
- Immunopharmacologic studies of D-penicillamine-L-cysteine disulfide.