Stress and immune responses. I. Suppression of T cell function in restraint-stressed mice.

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概要

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• Effects of restraint stress on humoral immune responses were investigated in mice. Mice were restrained for 12 hours per day at nighttime and released at daytime for 2 consecutive days, either before or after sheep red blood cell (SRBC) immunization. The antibody response to SRBC was markedly suppressed in mice that were restrained before antigen injection. In contrast, the response was not significantly affected when the stress was loaded after immunization. Oral administration of 10 mg/kg diazepam prevented the stress-induced suppression of anti-SRBC antibody response. On the other hand, antibody responses to T cell-independent antigens such as trinitrophenylated (TNP)-Ficoll and TNP-lipopolysaccharide were not suppressed. These results suggest that the restraint stress causes dysfunction of T cell populations in mice.

• 公益社団法人 日本薬理学会の論文

著者

• OKIMURA Tsutomu

  Research and Development Division, Morishita Jintan Co., Ltd.

• NIGO Yayoi

  Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University

関連論文

• Stress and immune responses. IV. Adrenal involvement in the alteration of antibody responses in restraint-stressed mice.
• Stress and immune responses. I. Suppression of T cell function in restraint-stressed mice.
• Stress and immune responses. II. Identification of stress-sensitive cells in murine spleen cells.
• Stress and immune responses. III. Effect of restraint stress on delayed type hypersensitivity (DTH) response, natural killer (NK) activity and phagocytosis in mice.

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