Blockade of enkephalinergic and GABAergic mediated locomotion in the nucleus accumbens by muscimol in the ventral pallidum.

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概要

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• The mu-opioid agonist, DAGO, and the indirect GABA<SUB>A</SUB> antagonist, picrotoxin, produced a dose-dependent increase in horizontal motor activity following injection into the nucleus accumbens that was independent of dopamine release. Injection of muscimol into the ventral pallidum antagonizes the motor stimulant effect of dopamine agonists. It was shown that muscimol abolished the locomotor stimulant effect of DAGO microinjection into the nucleus accumbens, and partially antagonized the effect of picrotoxin.

• 公益社団法人 日本薬理学会の論文

著者

• Austin Mark

  Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University

• Kalivas Peter

  Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University

関連論文

• Blockade of enkephalinergic and GABAergic mediated locomotion in the nucleus accumbens by muscimol in the ventral pallidum.

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