鼻腔及副鼻腔線毛上皮に関する研究 : 第1編 線毛上皮の生理機能
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概要
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The ciliated epithelium of the mucous membrane of the nasal cavities and paranasal sinuses of man and of rabbits were studied under a phase contrast microscope, in physiological state and with physical and chemical stimulation. The results of the studies were as follows :1) The ciliated cells were divided into two types: one was slender and 50 microns in length or longer, and the other was oval shaped and short. The former was mostly located in the vicinity of the ostium, while the latter was found mostly at the sinusal base. The ciliary movement was active in the former and slower in the latter. The average length of cilia was about 7 microns.2) When the cilia were in motion, the granule-stream in cytoplasm was observed at the cuticular border of the cells. The granules were small in number in the area below the nuclei.3) The cialiary movement was 380 to 460 per minute, and individual cell showed rotative or pendular movement, 4) In some of the cilia, the movement was not only .in horizontal direction but also vertical.The cells were flexible, and appeared to be regularly arranged in a small diamond shape fashion, one being at each of the four corners and one at the center of the diamond, here and there within the epithelium.5) The waves of the ciliary movement were recognized as light and dark dimples.6) The ideal solution for inclusion preservation of free cells was Ringers solution with 50%serum, added and then Ringers solution with 0.2% glucose. Distilled water and physiological saline solution were not satisfactory.7) The optimal temperature for individual free cells of man was 37°C, and for the ciliated epithelium of rabbits 33°C, being generally unstable in high temperature and stable in low temperature.8) The optimal pH was 7.6, being active in alkaline side and generally less active in acid side.9) The bionergy was diminished and weakened in the mucosa of maxillary sinuses with pus retention.10) In the mucosa in coses of allergic change, ciliary movement was active in some areas, but mostly depressed and loss of cilia was abserved in some areas.11) When adrenalin was added, the ciliated epithelium shrank but ciliary movement for about 1% hours.12) The ciliated epithelium reacted well to cocaine stimulation, and its cellular function stopped completely in several minutes after the stimulation. The change was irreversible to a reflux of physiological saline solution.13) The ciliated epithelium showed the same behavior to protargol as it did to the physiological saline solution used for its inclusion; no influence of the drug solution was observed.14) In case of stimulation by ammonium chloride, the cellular function instantly stopped, but was instantly recovered by a reflux of physiological saline solution.
- 社団法人 日本耳鼻咽喉科学会の論文