ウラニン試験による化膿性髄膜炎の診断及び予後判定に関する臨床的並びに実験的研究 : 第1編臨床的研究

概要

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Uranin solution (10%) was injected in four cases of otogenic suppurative meningitis, and two or three hours after the injection, content of uranin in the spinal liquid was measured by fluors- cope comparing the fluid with the standard solution in the light of ultra-violet (3600A) ray. The results of the examination were analysed in codsideration with other clinical findings and conclusions were as follows. 1.In case of healthy man, content of uranin in the spinal liquid was less than 10r/dl three hours after the intramuscular injection of 10% uranin solution in doses of 0.3cc per 1 kilogram body weight. 2.In case of otogenic suppurative meningitis, content of uranin was 60∼100r/dl while the disease was progressive, and the contents decreased when the patient had the tendency to recover, and at last when the content showed 10∼20r/dl, it was observed that the patient recovered with- out giving further medication. Then it could be concluded that when the content arrived at the level of 10∼20r/dl, the infl- ammation of meninges diminished and it was not necessary to give any medicament. 3.The uranin content was paralleled with the grade of globulin reaction of the fluid, but no relation between uranin content and the spinal pressure or number of cells in the fluid was observed. 4.It could be concluded that the measurement of uranin in the spinal fluid was valuable to establish diagnosis and prognosis of suppurative meningitis.