カナマイシンの聴力並に前庭機能障碍に就て

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Out of 19 patients who had been taking Kanamycin two suffered from subjective by-effects of deafness, tinnitus and urticaria, respectively, and one vertigo and the rest 14 patients suffered from no by-effect at all.By the audiogram disturvances were found in 14 patients(73.7%), 57.2% of which were in both sides of the ear.The amounts of dose, by which the deafness was caused, were 5-85g, mostly under 50g, and the deafness began within a period of 3 months.The degree of disturvance was in most cases slight with hearing loss of no more than 30db, and only 3 ears had hearing loss of 35_??_45db.The type of audiogram was mostly the gradual form, but the abrupt and the dip forms were also found.The region of the disturvance gradually increased at 2, 000c.p.s.and most of cases were disturbed in high tones above 6, 000c.p.s.In the use of medicine doses of less than 4g, per week there was no sign of regular tendency, but deafness was found among patients who were suffering from disorder in liver.The vestibular function showed no change in the Goniometry and the post-rotatory nystagmus test and yet there were some instances of small tendency of increase in the caloric nystagmus, but nothing significant was found in all.
社団法人日本耳鼻咽喉科学会の論文