酸素欠乏の蝸牛電位及び蝸牛神経活動電に及ぼす影響に関する実験的研究
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概要
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The experiments were performed in order to know the details of generation of the cochlear responses. The animal used were guinea pigs. Using the differential pre-amplifire and three stage differential ampifier after I. Tasaki, the cochlear microphonics (CM) and action potential (AP) were measured by means of vestibulo-tympanal recording under asphyxia. The results of investigations are as follows:1) Decrease of CM during asphyxia may be grossly divided into three phases, namely the unchangeble, the rapid diminished phase and the so called low level, which still persists for long period after death of animal. The former two are called CM, and the latter CM2.2) It was observed that the longer the period of asphyxia, the longer the time for recovery and moreover recovery was incomplate.3) Increaese of the stimulating tone from 30 to 40 phon did not show any change in decreasee or recovery of CM during asphyxia.4) With repeat of aspehyxia on same animal, the CM decrease became gradually more rapid and the recovery became slower and incomplete.5) Then the recording position was changed from basal to the third turn of cochlea and the stimulating tone frequency was boosted from 250 to 4000cps. But no change was noted in decrease nor in recovery of the CM during asphyxia.6) There were no difference of the phase between CM1 and CM2 during asphyxia.7) The preservation of energy, which the CM generation require, is very small.8) Both CM1 and CM2 are similarly influenced by the exposure to loud tone.9) If we conisder the behavior of the CM is due to the lack of oxygen, it seemes that the CM generation mechanism is biological.10) Resistance and recovery of AP N1, N2 for the lack of oxygen are weaker than that of CM in similar condition.
- 一般社団法人 日本耳鼻咽喉科学会の論文