振子様回転刺激によるフロセミドテストの臨床的ならびに実験的研究

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概要

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• For the purpose of detecting endolymphatic hydrops, the author developed "furosemide test for pendular rotation" (the furosemide test) and clinically applied the test on patients with Ménières disease and patients with other peripheral or central vertiginous disorders. It was also experimentally studied on guinea pigs with endolymphatic hydrops induced by surgical obliteration of unilateral endolymphatic sac and on normal ones. In the present report, the author concluded that this test would be a useful method for diagnosis of endolymphatic hydrops.1. Twenty seven out of 60 patients with Ménières disease (45%) were positive on the furosemide test. Of the above 60, 39 were tested in the attack stage and 25 (64%) were positive, but among the 21 patients tested in their remission stages, only 2 (10%) were positive.2. The patients with Ménières disease who had been positive on the furosemide test before the endolymphatic shunt operation all had uneventful post-operative courses without any further attacks.3. None of the 25 patients who had vertigo with other causes than Menieres disease were positive on the furosemide test whether they were in peripheral or central disorders.4. The guinea pigs with experimental endolymphatic hydrops induced by surgical obliteration of unilateral endolymphatic sac showed positive results in the furosemide test in a similar way as Menieres disease patients.5. The histological view of the inner ears of the guinea pigs with positive furosemide test revealed either normalizing or collapsing of the endolymphatic hydrops once produced in the affected ear, while the opposite ear was almost normal.6. In the control group of normal guinea pigs, the positive furosemide test was not found, and histologically the bilateral inner ears of them had almost normal endolymphatic space.

• 社団法人 日本耳鼻咽喉科学会の論文

著者

• 奥村 新一

  奈良県立医科大学耳鼻咽喉科学教室

関連論文

• 振子様回転刺激によるフロセミドテストの臨床的ならびに実験的研究
• メニエ-ル病に対するendolymphatic shunt operationの遠隔成績 (メニエ-ル病の研究-5-)
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• 小耳症に対する耳介形成手術の経験--肋軟骨フレ-ム法 (内藤儁教授退官記念論文集)
• Endolymphatic shunt operationにおけるFurosemide testの意義 (メニエ-ル病の研究-5-)
• 阪大における内リンパ嚢閉塞実験成績から--内リンパ嚢閉塞動物の機能検査 (メニエ-ル病の研究-6-)
• シリコン・ラバ-・フレ-ム法による小耳症耳介形成術の経験 (内藤儁教授退官記念論文集)
• メニエ-ル病のフロセミドテスト--中心および偏心振子様回転検査による (内藤儁教授退官記念論文集)

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