頭頸部惡性腫瘍のヌードマウスへの移植および実験的化学療法

概要

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Success rate of transplantation of head and neck cancer to BALB/C athymic mice was 42.2% (19/45). Based of the technical procedures, human squamous cell carcinomas with three different kinds of differentiations were transplanted to the mice and were used as chemotherapy models. These three kinds consisted of a well differentiated squamous cell carcinoma (ES-4), a moderately differentiated squamous cell carcinoma (OKK-2) and a poorly differentiated squamous cell carcinoma (PNC-1-JCK). Bleomycin (BLM) and Mitomycin C (MMC) were selected as chemotherapeutic agents and were given intraperitoneally either alone or in combination. Administration of BLM on day 1 and 4 in combination with MMC on day 1 was more effective. A schedule of administration of BLM for seven consective days followed by administration of MMC on day 8 enhanced chemotherapy effect more effectively.