聴覚刺激によるLate Positive Component (LPC)の研究 : 臨床応用の可能性について

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Three types of sound stimuli were contrived to improve an appearance rate of LPC (late positive component) in response to auditory stimuli.As a result, LPC appeared most frequently in SISI sounds, and the examination instrument could be simplified.LPC, CNV (cotingent negative variation) and RP (readiness potential) were simultaneously recorded as an event related potential using the SISI sounds.And the experiment was performed to investigate the relationship between the state of attention and the response, in relation to auditory evoked response, and the following conclusions were obtained. 1) According to investigation with various kind of sound stimuli, much attention of the subjects was needed to obtain the LPC, and the LPC was influenced by the state of consciousness and adaptation of subjects. 2) The latency of the LPC positive wave was 650 msec. This is similar to Gotos wave P650. The higher central nervous system seemed to be involved in production of this response, because for discriminating the complex sound stimuli. 3) Both P300 and P650 seemed to be the components of "LPC in a broad sense", because the whole process of LPC, observed in a longer analysis time, reached about 3500 msec. 4) Vertex seems to be the best position of a glittering electrode. Blink motion was considered not to influence results if a subject did not do it intentionally. 5) According to various kind of investigation, it is adequate to consider the negative potential change which occurred at two seconds before hearing sound stimuli as CNV rather than RP. 6) As a clinical application, LPC was considered to be useful for diagnosis of psychogenic deafness and stimulation as well as CNV. In addition, it was concluded that LPC can be objective indicator of attentiveness in SISI tests and various hearing tests.
社団法人日本耳鼻咽喉科学会の論文

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細谷睦
東京医科大学耳鼻咽喉科学教室

聴覚刺激によるLate Positive Component (LPC)の研究 : 臨床応用の可能性について

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