鼻におけるIgEによる反応の生体防御作用

概要

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Immunoglobulins of different classes are known to play a role in humoral defense mechanism, and Immunoglobulin E, without any actual evidence, is also expected to perform the same function.From the point of the defensive role, the present study was undertaken in nasal allergy by observing the way in which powdered carbon particles previously insufflated in the nasal cavity are rapidly removed in the nasal provocation test with causative allergen extract. The ratio of disappearance time of the carbon powder after/before the provocation test decreased markedly in good proportion with the intensity of the provocative reaction.Both sneezing and nasal secretion provocated by allergen contributed to this removal of the powder.When the nasal cavity in one side wastested, the non-tested side also showed a rapid disapp arance of the powder. In conclusion, Immunoglobulin E serves as a gate keeper by removing allergens from the surface of the nasal mucous membrane and by inhibiting the penetration of allergens into the nasal mucosa
社団法人日本耳鼻咽喉科学会の論文