中耳コレステリン肉芽腫の成因に関する研究

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In an experimental pathologic study, guinea pigs and rabbits were infused into the middle ear cavity: with the following stimuli (1) turpentine oil, (2) 3% FNa solution, (3) heparin, (4)cholesterin suspension, and (5) ferritin solution. The granuloma accompanying foam cells was observed in the animals treated with turpentine oil and 3% FNa solution. This finding is probably the step preceding the formation of cholesterin granuloma. Exudates from the cholesterin granuloma were biochemically assayed, cholesterin granulomas contained not not only cholesterols but also methemoglobin and storage iron due to hemorrhage. In the granulation tissue, fatty degeneration resulted from anoxia due to hemorrhage was observed. In view of these iesults, the etiology of cholesterin granuloma may be considered as follow: the constriction of the eustachian tube due to inflammation induces granulation at the aditus ad antrum in the antrum mastoideum; this produces a negative pressure in the middle ear cavity, which, in turn, causes peripheral circulatory failure and inflammation to occur, resulting in transdation of blood components, necrosis of the granulation tissue, and eventually the deposition of cholesterin; the occurrence of intragranular hemorrhage further leads to the deposition of storage iion and the appearance of methemoglobin, causing intragranular hypoxia, which eventually gives rise to fatty degeneration, depostion of cholesterin and appearance of giant cells and fibroblasts.
社団法人日本耳鼻咽喉科学会の論文

中耳コレステリン肉芽腫の成因に関する研究

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