シスプラチンマイクロカプセル微小血管化学塞栓療法

概要

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Cisplatin (CDDP) was microcapsulated with ethylcellulose. These CDDP-microcapsules (CDDP-m. c.) were prepared based on the principles of coacervation, with modification. Sustained release of CDDP from the microcapsule, especially non-protein-bound CDDP which has antitumor activity, was clearly demonstrated by an invitro test. By a bioassay method, it was proved that biological activity of CDDP was not affected by the micro-encapsulation process here employed. When CDDP-m. c. were infused into the maxillary artery of patients with carcinoma of maxillary sinus or oral cavity, CDDP level in the circulating blood was significantly lower than those of patients administered non-encapsulated CDDP intravenously. However, significantly high CDDP concentration in tumor tissue was found in the patients treated with CDDP-m. c. These results suggest that selective arterial infusion of CDDP-m. c. could exerts an intensive topical antitumor effects through microinfarction effect and prolonged drug release with decreased systemic side effect.