長時間反復回転刺激の半規管膨大部稜に及ぼす影響 : 感覚細胞の形態的変化とEwaldの法則の妥当性について

概要

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Twenty nine guinea pigs were used to investigate the effect of rotatory stimulation on the lateral crista ampullaris.After repeating the turning stimuli of cupulometric mode (maximum turning velocity: 450°/sec) for 48 hours, the functional and morphological changes of the crista ampullaris were investigated.Regarding the vestibular function, decrease in caloric response of ampullopetal side was more remarkable than that of ampullofugal side.The degenerative changes of sensory epithelium were observed initially in the top of the crista ampullaris by the morphological examination.Degeneration of mitochondria and the extension of endoplasmic reticulum were seen especially in supra-nuclear area.In a more advaned state of degeneration, the cytoplasm filled with vacuoles were observed.These degeneration were conspicuous in the type I cells than the type II cells.And, these findings in the crista ampullaris were more remarkable on the ampullopetal side than on the ampullofugal side.