等加速度回転刺激負荷時の前庭神経核及び小脳における糖消費量の変化に関するオートラジオグラフィーを用いた研究

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To know the excitability of the bilateral vestibular nuclei and the cerebellum for unidirectional acceleration, the autoradiographic study with [14C] 2-deoxy-D-glucose was performed for 3 control guinea pigs and 6 guinea pigs stimulated by clockweise constant acceleration of 1° or 2°/sec2.In this experiment, the following results were obtained1) The impuls from the horizontal semicircular canals produced the change of glucose uptake in the superior and medial vestibular naclei.Glucose uptake of the right side(the ampullopetal flow side) was increased as compared with control subjects, and that of the opposit side (the ampullofugal flow side) was decreased.Therefore, it was concluded that the excitability in the vestibular nucleus of the ampullopetal flow side was higher than one of the ampullofugal flow side and the valibility of Ewald's law was noticed in not only the horizontal semicircular canals but also a level of the vestibular nuclei.2) Although slight elevation of glucose uptake in the cerebellar nodulus of the ampullofugal flow side was observed by the rotatostimulation, this change was not significant at P<0-01.All cerebellar nuclei, especially in the fastigeal nucleus, showed a decrease of glucose uptake in the both sides by the rotational stimulation.
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