Effect of the change in the perilymphatic ionic composition on the N1 response of guinea pig: The second report, calcium change.:PIG: THE SECOND REPORT, CALCIUM CHANGE

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The effect of the lowered Ca2+ concentration in perilymph on N1 and CM was investigated in 11 guinea pigs. The scala tympani was perfused with an artificial perilymph containing various concentrations of Ca2+ and this concentration was monitored by ion-selective microelectrodes during the experiment.With the decrease of Ca2+ concentration in perilymph, the elevation of the threshold, the decrease of the amplitude and the prolongation of the latency were significantly recognized in N1. After the standstill of a perfusion with a low-Ca2+ solution, the N1 response gradually recovered toward the initial value. In spite of the significant effect on N1, the perfusion with a low-Ca2+solution had a little effect on CM.The N1 changes are considered to be caused by the inhibition of transduction and the disturbance of the afferent synaptic transmission due to the inhibition of Ca2+ influx to hair cells.
一般社団法人日本耳鼻咽喉科学会の論文